Yes. Be sure that:

The virtual machine has the correct permissions so that ExtendSim can be installed without security issues.

The location where user-modifiable files will be installed has read-write access so ExtendSim can read the license file and the end user can open, run, and save models.

 

Note: The Trial version of ExtendSim cannot be installed on a virtual machine or on a Macintosh running Windows through Parallels or similar emulator. Only activated licenses will run on VMs.