As biotechnology organizations have successfully launched new products, the challenges of producing adequate quantities have grown. Simulation is a powerful tool that can offer many benefits if done right and used appropriately. This general overview compares static and dynamic modeling and their usefulness in the biotechnology field.

Computer Simulation Modeling of Recreation Use: Current Status, Case Studies, and Future Directions

A Discrete Event Simulation of a Municipal Street Tree Maintenance Operation

Inventory management of multi-echelon repairable item structures has been largely studied. Restrictions on its applications to real case problems were difficult to overcome. To surpass some of these limitations, the authors used Extend to create a simulation model that not only examines a multi-echelon structure system, but also permits the explicit consideration of a hierarchical structure for repairable and consumable items. Model results balance inventory policy which guarantees a certain level of service accounting for operations occurrence and repairs conditions.

A quick-service restaurant chain's use of simulation shows corporate management every step in each kitchen to allow them to develop work schedules that assures freshness of food products even with the addition of new menu items.

The Balanced Scorecard Economic Value Added (EVA) Model is a comprehensive and fully integrated financial analysis tool designed to provide the backbone and baseline for reengineering and operations improvements. This article describes this type of model using examples from a model designed around the organizational framework of a large utility company operating via Strategic Business Units (SBUs).

Computer Simulation Modeling for Recreation Management: A Study on Carriage Road Use in Acadia National Park, Maine, USA

Dynamic Simulator for WIP Analysis in Semiconductor Manufacturing

Case study in which a simulation project manager wanted to determine current plant capacity and be able to test the effects of various changes. This article discusses models that examined the balance between the "making" and "packing" systems during an annual production cycle.

Good overview paper on the use of Extend in lean manufacturing. Defines simulation and highlights a few areas where it can be most valuable.

Simulation modeling is a tool of hospital-wide system process change with a focus on improving patient satisfaction through a better clinical process. Some of the improvements, based on existing systems, include decreased delays, better healthcare staff utilization and tailored scheduling. In this part 2 of 2 perioperative case studies (part 1: Ambulatory Surgery Unit), the experiences of three distinct, yet complimentary professions are combined and opitimized: nursing/healthcare planning, architecture, and simulation engineering to create a better way to provide a clinical service in a newly designed healthcare space. Complete paper to be posted soon.

Combining Simulation with RTN Optimization for Multi-product Chemical Processes

In this paper, NETE -- a Net-Centric Warfare (NCW) End-to-End model is discussed. NETE is a medium fidelity constructive simulation of the Global Information Grid (GIG) infrastructure, Service networks, and their integrated operations in support of definable mission areas. The NETE model provides a means to assess the ability of a defined network to support a concept of operations with resource management to allow the assessment of latencies under varying loads. NETE also calculates the impact of network ‘jitter’ on mission timelines.

Zapping System Bugs Through Performance Engineering

A group of engineers at MITRE collaborated and are emphasizing how the performance engineering (PE) practice assures systems meet their operational performance goals. To that end, MITRE engineers have developed a number of PE tools, such as the Modeling Environment for SOA Analysis (MESA). MESA (developed in Extend) provides end-to-end modeling and simulation environments for studying service-oriented architectures (SOA).

D.S.F. Neves, A.P.D. Gomes, L.A.C. Tarelho, and M.A.A. Matos
Department of Environment and Planning, University of Aveiro, Portugal

Presented at the Eleventh International Waste Management and Landfill Symposium
October 2007

The composting process applied to the treatment of biodegradable waste materials is one of the most adequate ways to enhance the environmental performance of the municipal solid waste (MSW) management systems. In the European context where environmental policies tend to encourage solid waste minimization and recycling, home composting is an effective method to decrease the quantity of MSW to be disposed. Home composting can be used for the conversion of the organic fraction of household wastes to a stable humus-like material (the compost).

This paper presents a dynamic model that simulates the biological composting process, applied to the organic fraction of the municipal solid waste.

Results from the sCOMPOS model.

Computer Simulation Modeling for Recreation Management: A Study on Carriage Road Use in Acadia National Park, Maine, USA

Evaluating Low Impact Development Practices for Stormwater Management on an Industrial Site in Mississippi

An energetic materials environmental study was completed with participation from NASA, the Environmental Protection Agency, and others to define the environmental impact of energetic materials. The Extend model developed for this project helped to identify eleven areas for which The Strategic Environmental Research and Development Program (SERDP) might consider promoting future research and development work, plus the model calculated the propellant cost for each manufacturing activity.

Developed in Extend, the LIFE (Low Impact Feasibility Evaluation) model establishes functional connections between different land uses and landscape features. It can be used for:

	Design of volume or water quality based stormwater controls.
	Review of development/re-development plans for compliance with stormwater regulations.
	Incentive-based approaches such as environmental credit trading.
	Public education and outreach.

The Indian Head Division Naval Surface Warfare Center (IHD/NSWC) contracted the National Defense Center for Environmental Excellence (NDCEE) to develop a process and environmental cost-analysis simulation for gun propellant processing. Using Extend, they built a model specific to the extrusion of both solvent and solventless thermoplastic elastomer (TPE) propellants. This model accurately predicts the cost impacts of alternative processes before implementation can be initiated.

Using Extend, the authors constructed a system model, MOSIM, that uses the physical reservoir data and minimum releases for hydropower and environmental constraints from a long-term study of the Missouri River basin. The value was based on the hydropower generated by the main-stem dams for a simulated period of 1898–1996 using MOSIM. Simulated forecasted flows were generated to represent the levels of predictability that had been determined in a previous study. The results demonstrate that use of climate forecast information along with better definition of the basin moisture states can improve runoff predictions with modest economic value that, in general, will increase as the size of the reservoir system decreases.

In collaboration with a major utility facing major storms on an annual basis, Davies Consulting Inc. developed an innovative simulation model that allows decision makers to evaluate the affect of strategic decisions on storm restoration prior to and after a storm has struck.

Facility Design: Simulation Methodology for Facility Design
How simulation software can be used effectively as a capacity planning and design tool.

Designing a new biological facility or planning the expansion of an existing one requires evaluation of several parameters related to product characteristics, equipment capability, and facility capacity. Decisions made at the design stages are critical to the validation plan and the ongoing operation if it is a commercial facility. Whether the facility will provide the needed future capacity is one of the critical questions requiring a credible answer. This article describes a methodology that uses Extend simulation software as a capacity planning and design tool.

A quick-service restaurant chain's use of simulation shows corporate management every step in each kitchen to allow them to develop work schedules that assures freshness of food products even with the addition of new menu items.

Packages that accurately emulate the hybrid processes that characterize food and beverage manufacturing are making simulation more than just a snazzy presentation tool for upper management. Users are roughing out their production and packaging lines on screen to gain insight into the dynamics of their lines and where and why bottlenecks occur.

Air Mail Facility Simulation

Extend Helps Contractor Save Money

Simulation developed for the United States Postal Service that examines labor and equipment costs associated with the implementation of a new service in various demographic areas and predicts when this service would result in a return on invested capital.

An energetic materials environmental study was completed with participation from NASA, the Environmental Protection Agency, and others to define the environmental impact of energetic materials. The Extend model developed for this project helped to identify eleven areas for which The Strategic Environmental Research and Development Program (SERDP) might consider promoting future research and development work, plus the model calculated the propellant cost for each manufacturing activity.

In this paper, NETE -- a Net-Centric Warfare (NCW) End-to-End model is discussed. NETE is a medium fidelity constructive simulation of the Global Information Grid (GIG) infrastructure, Service networks, and their integrated operations in support of definable mission areas. The NETE model provides a means to assess the ability of a defined network to support a concept of operations with resource management to allow the assessment of latencies under varying loads. NETE also calculates the impact of network ‘jitter’ on mission timelines.

Discrete Event Modeling of CD4+ Memory T Cell Generation

Discrete Event Simulation of Emergency Department Activity: A Platform for System-level Operations Research

A large hospital in southeast United States utilized simulation to aid project leaders in advancing to the next level of sophistication with Six Sigma. The project produced an ongoing, workable model from which potential process improvements in their Emergency Department (ED) were simulated. Project leaders tested several scenarios in the ED Simulation to quantify their value proposition. The simulation model also enabled the hospital to test design ideas of a planned new facility.

This case study demonstrates the value of simulation modeling in the healthcare architecture design of a new ambulatory surgery unit. The simulation developed explores the relationship between the number of operating rooms and recovery beds, the number of cases and the phases of recovery, bed capacity, staffing, and waiting room seat requirements as each affected the design. Model results allowed time for variations in the design to meet the client's needs before the project was built. Furthermore, the simulation shows the positive outcome of combining the experience of three professional disciplines: healthcare planning, architecture, and simulation modeling for nurses, doctors and patients of the new ambulatory surgery unit.

Simulation modeling is a tool of hospital-wide system process change with a focus on improving patient satisfaction through a better clinical process. Some of the improvements, based on existing systems, include decreased delays, better healthcare staff utilization and tailored scheduling. In this part 2 of 2 perioperative case studies (part 1: Ambulatory Surgery Unit), the experiences of three distinct, yet complimentary professions are combined and opitimized: nursing/healthcare planning, architecture, and simulation engineering to create a better way to provide a clinical service in a newly designed healthcare space. Complete paper to be posted soon.

Flow architecture simulation: a powerful approach to buffer dimensioning in high-speed packaging lines

Inventory management model developed for a growing industrial manufacturer.

Simulation of a wafer fabrication line to assist in the meeting of delivery schedules, reducing product cycle times, increasing product yield and throughput, optimizing equipment utilization, and increasing confidence for on-time delivery and profits.

1.45 MB

Inventory management of multi-echelon repairable item structures has been largely studied. Restrictions on its applications to real case problems were difficult to overcome. To surpass some of these limitations, the authors used Extend to create a simulation model that not only examines a multi-echelon structure system, but also permits the explicit consideration of a hierarchical structure for repairable and consumable items. Model results balance inventory policy which guarantees a certain level of service accounting for operations occurrence and repairs conditions.

Brief introductory article discussing the key element in lean implementation: simulation.

Working as a team, Crutchfield Corporation, a major consumer electronics catalog and Internet retailer, and Rust Management Technology used Extend and ExpertFit to develop and validate a distribution center process simulation using Six Sigma techniques. Using insights developed through the simulation, Crutchfield Corporation estimates that it will save 15 to 20 times the cost of the project in the first year after deployment. Paper is currently not available online.

This paper presents a case study where simulation was used to convert from a manufacturing resource planning (MRP) based push process to a demand-driven pull process in a single plant operation factory floor.

Introduces the use of simulation models as essential tools for lean programs to test alternative solutions before implementing them. Mr. Curry highlights benefits of using Extend and includes screenshots of numerous sample models.

A large hospital in southeast United States utilized simulation to aid project leaders in advancing to the next level of sophistication with Six Sigma. The project produced an ongoing, workable model from which potential process improvements in their Emergency Department (ED) were simulated. Project leaders tested several scenarios in the ED Simulation to quantify their value proposition. The simulation model also enabled the hospital to test design ideas of a planned new facility.

Good overview paper on the use of Extend in lean manufacturing. Defines simulation and highlights a few areas where it can be most valuable.

Wine Business Monthly
October 2000

Development and implementation of integrated biomass supply analysis and logistics model (IBSAL)

The Guardian Installation Protection Program (IPP), a program within the Joint Program Executive Office for Chemical and Biological Defense to protect 200 military installations world-wide from chemical, biological, and radiological threats, developed and accredited the IPP System Effectiveness Model. This model helps evaluate installation designs and make programmatic decisions. It assists a product manager to make a myriad of acquisition and design decisions and measure the performance of a design before it is fielded. By catching key design flaws before they are fielded, analysis can be performed to help define alternative operational procedures and new design requirements early in the acquisition process and avoid fielding delays and unexpected costs. This innovative toolset is the first of its kind that has the ability to effectively model complex military environments, multiple threats, and innovative designs that combine materiel and non-materiel components into one Family of Systems.

Boeing and the Naval Postgraduate School (NPS) developed an Extend model of an organizational concept called Standing Joint Forces HQ (SJFHQ) being developed at the U.S. Joint Forces Command (JFCOM). The modeling objective was to measure personnel utilization